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Cat. No. Product Name Target Signaling Pathways
T35809 C20 Sphingomyelin (d18:1/20:0)

C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m...
T35804 C16 Lactosylceramide (d18:1/16:0)

C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.

化合物

C20 Sphingomyelin (d18:1/20:0)
Cat.No: T35809
Synonym:
Target:
C16 Lactosylceramide (d18:1/16:0)
Cat.No: T35804
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-00131 Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)

NPC,Niemann-Pick disease, typ...

Human HEK293 Cells
Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick ty...

重组蛋白

Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)
Cat.No: TMPY-00131
Species: Human
Expression System: HEK293 Cells
TargetMol Loading
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